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MIETHKE XABO®
Antibiotic Impregnated Catheters – Xtra Protection Against Infection

One of the most common and potentially serious complications of hydrocephalus treatment is an infection of the shunt [1], affecting 7-15% of hydrocephalus patients [3]. This complication affects pediatric as well as adult patients and impairs their quality of life, cognitive function, and shunt survival [2]. Shunt infections mostly require removal of the shunt, antibiotic treatment and reimplantation [2].

Shunt infections can have severe consequences for the patient: They are associated with a higher risk for further complications, such as seizures, psychomotor retardation, and shunt failure, which increase morbidity and mortality [6–9]. For the neurosurgeon, shunt infections drastically increase the workload and in the worst-case scenario require additional unplanned surgeries.

Use of antibiotic-impregnated catheters can prevent two-thirds of shunt infections [11], thus helping to reduce patient burden and improve patient outcome.

MIETHKE’s new antibiotic-impregnated catheter XABO uses a balanced ratio of clindamycin hydrochloride and rifampicin to effectively fight gram-positive bacteria [12].

XABO antibiotic impregnated catheters offer long-lasting antimicrobial effects, easy handling, convenient storage and perfectly fit all our innovative MIETHKE valves. Patients can benefit from XABO’s optimized release kinetics: the antibiotics are released continuously over at least 38 days after implantation [14], ensuring that XABO’s antimicrobial activity covers the time window when the patient is most susceptible to infection [1, 15-17]. The high potency of the antibiotic impregnation allows for the release of low antibiotic doses, which prevents allergic reactions and minimizes the risk of resistance development.

XABO’s initial antibiotic loading is retained thanks to the gentle sterilization process. In addition, XABO comes wrapped in a specifically designed complete package combination that minimizes degradation products [13], ensuring the antibiotic-impregnated catheter is kept in prime condition for longer. Thanks to the gentle sterilization process and safe packaging it is storable for up to 36 months and withstands temperatures up to 30°C without losing its effectiveness [18].

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One of the most common and potentially serious complications of hydrocephalus treatment is an infection of the shunt [1], affecting 7-15% of hydrocephalus patients [3]. This complication affects pediatric as well as adult patients and impairs their quality of life, cognitive function, and shunt survival [2]. Shunt infections mostly require removal of the shunt, antibiotic treatment and reimplantation [2].

Shunt infections can have severe consequences for the patient: They are associated with a higher risk for further complications, such as seizures, psychomotor retardation, and shunt failure, which increase morbidity and mortality [6–9]. For the neurosurgeon, shunt infections drastically increase the workload and in the worst-case scenario require additional unplanned surgeries.

Use of antibiotic-impregnated catheters can prevent two-thirds of shunt infections [11], thus helping to reduce patient burden and improve patient outcome.

MIETHKE’s new antibiotic-impregnated catheter XABO uses a balanced ratio of clindamycin hydrochloride and rifampicin to effectively fight gram-positive bacteria [12].

XABO antibiotic impregnated catheters offer long-lasting antimicrobial effects, easy handling, convenient storage and perfectly fit all our innovative MIETHKE valves. Patients can benefit from XABO’s optimized release kinetics: the antibiotics are released continuously over at least 38 days after implantation [14], ensuring that XABO’s antimicrobial activity covers the time window when the patient is most susceptible to infection [1, 15-17]. The high potency of the antibiotic impregnation allows for the release of low antibiotic doses, which prevents allergic reactions and minimizes the risk of resistance development.

XABO’s initial antibiotic loading is retained thanks to the gentle sterilization process. In addition, XABO comes wrapped in a specifically designed complete package combination that minimizes degradation products [13], ensuring the antibiotic-impregnated catheter is kept in prime condition for longer. Thanks to the gentle sterilization process and safe packaging it is storable for up to 36 months and withstands temperatures up to 30°C without losing its effectiveness [18].